Enantiospecific Intramolecular Heck Reactions of Secondary Benzylic Ethers

نویسندگان

  • Michael R. Harris
  • Mikhail O. Konev
  • Elizabeth R. Jarvo
چکیده

Enantioenriched methylenecyclopentanes are synthesized by stereospecific, nickel-catalyzed Heck cyclizations of secondary benzylic ethers. The reaction proceeds in high yield and enantiospecificity for benzylic ethers of both π-extended and simple arenes. Ethers with pendant 1,2-disubstituted olefins form trisubstituted olefins with control of both absolute configuration and alkene geometry. Diastereoselective synthesis of a polycyclic furan is demonstrated.

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عنوان ژورنال:

دوره 136  شماره 

صفحات  -

تاریخ انتشار 2014